The term “bug bite” is commonly used to denote both bites and stings inflicted by members of the phylum Arthropoda.  Arthropods make up the largest division of the animal kingdom, representing approximately 80% of all known animals. Defining characteristics include the presence of an exoskeleton, jointed appendages, and a body composed of specialized regional segments.

The four medically significant classes of arthropods are Chilopoda, Diplopoda, Insecta, and Arachnida. Of these, the insects, which represent more than half of all living organisms, and the arachnids have the greatest clinical impact on humans.

Erythematous and edematous eruptions along with other dermatological findings such as papules and urticaria represent the most common clinical manifestations of arthropod bites and stings.  In some cases, the delivery of toxic venom can result in significant systemic reactions including autonomic instability, neurotoxicity and organ failure.  The acute development of anaphylactic reactions can be rapidly fatal, most commonly due to angioedema or circulatory collapse.  In these cases, rapid recognition and treatment with epinephrine are critical.  The most clinically significant impact of arthropod bites is their ability to serve as vectors for numerous bacterial, viral, and protozoal diseases.

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Etiology

The consequences of arthropod bites are generally due to traumatic injury or local inflammation and hypersensitivity to arthropod saliva. Even though some arthropods are capable of injecting venom when biting, most envenomation occurs via a stinger connected to a venom gland.  Notable arthropods possessing stingers include bees, wasps, hornets, fire ants, and scorpions.  Both bites and stings create tissue injury which can serve as a portal of entry for secondary bacterial infection.

The four classes medically significant arthropods are the chilopods, diplopods, insects, and arachnids.

Chilopods

Characteristic Description
Organism Centipedes (Chilopods)
Biting Structure Cephalad biting structure connected to a venom gland
Clinical Manifestations Two hemorrhagic punctures with surrounding erythema and swelling
Venom Components Biochemical mediators, including metalloproteases
Symptoms Immediate localized pain
Treatment - Cleaning with soap and water
- Local application of ice
- Topical steroids
- Pain management with acetaminophen or NSAIDs
Severe Pain Treatment Local infiltration of lidocaine

Diplopods

Characteristic Description
Organism Millipedes (Diplopods)
Damage Mechanism Secretion of toxic liquid from glands on body segments causing caustic-like effect to tissues
Clinical Manifestations Intense burning sensation, erythema, occasionally vesicle formation, and localized hyperpigmentation (brown or black)
Severe Injury Ocular exposure can cause chemical conjunctivitis or corneal ulceration
Treatment - Washing area with soapy water immediately after exposure

Insecta

Members of the class Insecta, which comprise approximately 60% of all arthropod species, include Hymenoptera (bees, wasps, hornets and fire ants), mosquitoes, bed bugs, fleas, lice, beetles, caterpillars and moths, and kissing bugs.

Characteristic Description
Organism Caterpillars and Moths
Damage Mechanism Contact with protective hairs or spines
Clinical Manifestations Erythema, pruritus, papules, urticaria, local burning pain, hemorrhagic purpuric papules
Treatment - Ice application
- Topical corticosteroids
- Systemic antihistamines
- NSAIDs or acetaminophen
- Removal of hairs or spines with adhesive tape
Characteristic Description
Organism Cimex lectularius (Human Bedbug)
Damage Mechanism Blood feeding
Clinical Manifestations Small papule or punctum, usually without surrounding reaction
Treatment - Topical glucocorticoids
- Systemic antihistamines
- Antibiotics for secondary infections
- Professional insecticide and nonchemical controls
Characteristic Description
Organism Triatome Bugs (Kissing Bugs)
Damage Mechanism Blood feeding, transmission of Trypanosoma cruzi
Clinical Manifestations Papules with hemorrhagic puncta or vesiculobullous lesions, chagoma
Treatment - Symptomatic care for pruritus and pain
- Address Chagas disease complications
Characteristic Description
Organism Head Lice, Pubic Lice, Body Lice
Damage Mechanism Blood feeding
Clinical Manifestations Itching, sensation of movement, nits or lice visible
Treatment - Pediculicides
- Oral ivermectin
- Fine comb for nit removal
- Hygiene improvements for body lice
- Antibiotics for secondary infections
Characteristic Description
Organism Mosquitoes
Damage Mechanism Blood feeding
Clinical Manifestations Urticarial wheals, pruritus
Treatment - Ice application
- Topical corticosteroids
- Systemic antihistamines